Arquette was born in a Subud commune in Bentonville, Virginia. He is the youngest child of Brenda "Mardi" Olivia (née Nowak), an actor, poet, theatre operator , activist, acting teacher, and therapist, and Lewis Arquette, an actor. Arquette's paternal grandfather was comedian Cliff Arquette.Arquette's mother was Jewish (from a family that emigrated from Poland) 阿奎特出生在弗吉尼亞州本頓維爾的一個蘇布德公社。   他是演員、詩人、劇院經營者、活動家、表演教師和治療師布倫達“狂歡節”奧利維亞（原名諾瓦克）和演員劉易斯阿奎特的最小孩子。  阿奎特的祖父是喜劇演員克里夫·阿奎特。阿奎特的母親是猶太人（來自波蘭移民家庭）
Arquette's four siblings, Rosanna, Richmond, Patricia, and Alexis, all became actors as well.Arquette 的四個兄弟姐妹 Rosanna、Richmond、Patricia 和 Alexis 也都成為了演員。 The Arquettes had an unusual upbringing,with a father who occasionally had issues with substance abuse.[ Arquettes 有一個
Arquette appeared in a number of movies in the 1990s,including Buffy the Vampire Slayer (1992), Airheads (1994) and Never Been Kissed (1999).阿奎特出現在 1990 年代的多部電影中，包括吸血鬼獵人巴菲 (1992)、空頭 (1994) 和從未被親吻 (1999)。
He had guest spots on television shows like Blossom (1992),Beverly Hills, 90210 (1992) and Friends (1996).Arquette achieved his biggest success in the horror/slasher film franchise Scream. It was during the filming of the first film in 1996 that he first met his future wife, Courteney Cox. The couple married in 1999; 他在 Blossom (1992)、Beverly Hills, 90210 (1992) 和 Friends (1996) 等電視節目中擔任客串。阿奎特在恐怖/恐怖電影系列《尖叫》中取得了他最大的成功。 在 1996 年拍攝第一部電影期間，他第一次遇到了未來的妻子柯特妮·考克斯。這對夫婦於 1999 年結婚；
The couple married in 1999; together, they appeared in a 2003 advertisement for Coke and formed the production company Coquette (both a portmanteau of their last names and a word meaning a flirty woman), which has produced a number of films and television series, 這對夫婦於 1999 年結婚；他們一起出現在2003 年的可口可樂廣告中，並成立了製作公司 Coquette（既是他們姓氏的混合詞，又是一個表示性感女人的詞）， 該公司製作了許多電影和電視連續劇，
Arquette married actress Courteney Cox on June 12, 1999. They have a daughter, Coco Arquette, born in 2004. Jennifer Aniston is Coco's godmother. On October 11, 2010, the media announced that Arquette and Cox were having a trial separation, but "still love each other deeply." In June 2012, Arquette filed for divorce after nearly two years of separation from Cox
阿奎特於 1999 年 6 月 12 日與女演員柯特妮考克斯結婚。 他們有一個女兒 Coco Arquette，出生於 2004 年。詹妮弗安妮斯頓是可可的教母。  2010年10月11日，媒體宣布阿奎特和考克斯試探性分居，但“仍然深愛對方。” 2012年6月，阿奎特在與考克斯分居近兩年後提出離婚。
The divorce became final in May 2013. He final in May 2013. He started dating Entertainment Tonight correspondent Christina McLarty in 2011. They announced they were expecting their first child together in November 2013.McLarty gave birth to the couple's son in 2014. The couple announced their engagement in July, 2014.They were married on April 12, 2015. McLarty gave birth to their second son in 2017.